Gna13 (NM_010303) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR205863L3V
- LentiORF®
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Lenti ORF particles, Gna13 (Myc-DDK-tagged) - Mouse guanine nucleotide binding protein, alpha 13 (Gna13), 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
AAV Particle: DDK
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Specifications
Product Data | |
Type | Mouse Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | Gna13 |
Synonyms | AU024132; AU043124; Galpha13 |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_010303 |
ORF Size | 1134 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR205863).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_010303.3 |
RefSeq Size | 6217 bp |
RefSeq ORF | 1134 bp |
Locus ID | 14674 |
UniProt ID | P27601 |
Cytogenetics | 11 71.88 cM |
Gene Summary | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:21212405, PubMed:19151758, PubMed:16388592). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:16388592). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (PubMed:19151758, PubMed:21212405). Promotes tumor cell invasion and metastasis by activating Rho/ROCK signaling pathway (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity).[UniProtKB/Swiss-Prot Function] |
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