Dkk1 (NM_010051) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR203629L4V

Lenti ORF particles, Dkk1 (GFP-tagged) - Mouse dickkopf homolog 1 (Xenopus laevis) (Dkk1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Dkk1
• Synonyms: mdkk-1
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_010051
• ORF Size: 819 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR203629).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_010051.3, NP_034181.2
• RefSeq Size: 2245 bp
• RefSeq ORF: 819 bp
• Locus ID: 13380
• UniProt ID: O54908
• Cytogenetics: 19 C1
• Gene Summary: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed:18505822).[UniProtKB/Swiss-Prot Function]