PTPH1 (PTPN3) (NM_001145368) Human Untagged Clone

CAT#: SC325366

PTPN3 (untagged)-Human protein tyrosine phosphatase, non-receptor type 3 (PTPN3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPH1
• Synonyms: PTP-H1; PTPH1
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001145368, the custom clone sequence may differ by one or more nucleotides
  ATGACCTCCCGGTTACGTGCGTTGGGTGGAAGAATTAATAATATACGCACCTCGGAGTTA
  CCCAAAGAGAAAACTCGATCAGAAGTCATTTGCAGCATCCACTTTTTAGATGGCGTGGTA
  CAGACCTTTAAAGTTACTAAACAAGACACTGGCCAGGTTCTTCTGGATATGGTGCACAAC
  CACCTGGGTGTGACTGAAAAGGAATATTTTGGTTTACAGCATGATGACGACTCCGTGGAC
  TCTCCTAGATGGCTGGAAGCAAGCAAAGCCATCAGGAAGCAGTTAAAAGGAGGTTTCCCC
  TGTACCCTGCATTTTCGAGTAAGATTTTTTATACCTGATCCCAACACACTGCAGCAAGAA
  CAAACCAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACC
  TGCCCTCTTAACTCAGCAGTGGTTCTAGCGTCCTATGCCGTACAATCTCATTTTGGAGAC
  TATAATTCTTCCATACATCATCCAGGCTATCTTTCCGATAGTCACTTTATACCCGATCAA
  AATGAGGACTTTTTAACAAAAGTCGAATCTCTGCATGAGCAGCACAGTGGGCTAAAACAA
  TCAGAAGCAGAATCCTGCTATATCAACATAGCGCGGACCCTCGACTTCTATGGAGTAGAA
  CTGCACAGTGGTAGGGATCTGCACAATTTAGACCTAATGATTGGAATTGCTTCCGCGGGT
  GTTGCTGTGTACCGAAAATACATTTGCACAAGTTTCTATCCTTGGGTGAACATTCTCAAA
  ATTTCTTTCAAAAGGAAAAAGTTCTTCATACATCAGCGACAGAAACAGGCTGAATCCAGG
  GAACATATTGTGGCCTTCAACATGCTGAATTACCGATCTTGCAAAAACTTGTGGAAATCC
  TGTGTTGAGCACCATACGTTCTTTCAGGCAAAGAAGCTACTACCTCAGGAAAAGAATGTT
  CTGTCTCAGTACTGGACTATGGGCTCTCGGAACACCAAAAAGCGAAGTCCTCGGCTCCGG
  CACGAAATCCGAAAGCCACGCCACTCTTCTGCAGATAACCTTGCAAATGAAATGACCTAC
  ATCACGGAAACGGAAGATGTATTTTACACGTACAAGGGCTCTCTGGCCCCTCAAGACAGC
  GATTCTGAAGTTTCTCAGAACCGAAGCCCGCACCAAGAGAGTTTATCCGAGAACAATCCG
  GCACAAAGCTACCTGACCCAGAAGTCATCCAGTTCTGTGTCTCCATCTTCAAATGCTCCA
  GGCTCCTGCTCACCTGACGGCGTTGATCAGCAGCTCTTAGATGACTTCCACAGGGTGACC
  AAAGGGGGCTCCACCGAGGACGCCAGCCAGTACTACTGTGACAAGAATGATAATGGTGAC
  AGCTACTTAGTCTTGATCCGTATCACACCAGATGAAGATGGAAAATTTGGATTTAATCTT
  AAGGGAGGAGTGGATCAAAAGATGCCTCTTGTGGTATCAAGGATAAACCCAGAGTCACCT
  GCGGACACCTGCATTCCTAAGCTGAACGAAGGGGATCAAATCGTGTTAATCAATGGCCGG
  GACATCTCAGAACACACGCATGACCAAGTGGTGATGTTCATCAAAGCCAGCCGGGAGTCC
  CACTCACGGGAGCTGGCCCTGGTGATCAGGAGGAGAGCTGTCCGCTCATTTGCTGACTTC
  AAGTCTGAAGATGAACTGAACCAGCTTTTCCCCGAAGCCATTTTCCCCATGTGTCCGGAG
  GGTGGGGACACTTTGGAGGGATCCATGGCACAGCTAAAGAAGGGCCTCGAAAGCGGGACG
  GTGCTGATCCAGTTTGAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCA
  AAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTGCCTTATGACACCACC
  CGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATT
  CCTGCTGCTAACCTTGTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGT
  GCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATTGTCATGTTGACGACT
  CTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATG
  AACCACGGCGGCTTTCACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCC
  CGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACAGTGACACATCTCCAG
  TACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTA
  AACTATGTGAGGTCTCTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGA
  ATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGCCTAACTGAGAGGAAC
  CTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTG
  CAGACATCAAGCCAGTACAAGTTTGTGTGTGAAGCGATTCTTCGTGTGTATGAAGAAGGT
  TTAGTCCAAATGCTGGATCCTAGT
  
• Restriction Sites: Please inquire
• ACCN: NM_001145368
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001145368.1, NP_001138840.1
• RefSeq Size: 6599 bp
• RefSeq ORF: 2607 bp
• Locus ID: 5774
• UniProt ID: P26045
• Cytogenetics: 9q31.3
• Protein Families: Druggable Genome, Phosphatase
• Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
  Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.