Ubiquilin (UBQLN1) (NM_053067) Human Untagged Clone

CAT#: SC320548

UBQLN1 (untagged)-Human ubiquilin 1 (UBQLN1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Ubiquilin
• Synonyms: DA41; DSK2; PLIC-1; UBQN; XDRP1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_053067.1 CGGATGTCGGTGTGAGCGAGCGGCGCCTGAACACACGGCGGCTGCCGAGCGCCTGACCCG
  GGCCTGCGCCAGAGCCTGCACCGAGCTCCGGGGCCCCACACCCGCTACGGTGGCCCTGCG
  CCCGTTGCTACTGAGGCGGCGTGCTCTGCATTCTTCGCTGTCCAGGCCTGCCGGCTCTGG
  TGTCTGCTGGCTCCTCCTTGCTCGCCTGCTCCCTCCTGCTTGCCTGAGTCACCGCCGCCG
  CCGCCGCCACAGCCATGGCCGAGAGTGGTGAAAGCGGCGGTCCTCCGGGCTCCCAGGATA
  GCGCCGCCGGAGCCGAAGGTGCTGGCGCCCCCGCGGCCGCTGCCTCCGCGGAGCCCAAAA
  TCATGAAAGTCACCGTGAAGACCCCGAAGGAAAAGGAGGAATTCGCCGTGCCCGAGAATA
  GCTCCGTCCAGCAGTTTAAGGAAGAAATCTCTAAACGTTTTAAATCACATACTGACCAAC
  TTGTGTTGATATTTGCTGGAAAAATTTTGAAAGATCAAGATACCTTGAGTCAGCATGGAA
  TTCATGATGGACTTACTGTTCACCTTGTCATTAAAACACAAAACAGGCCTCAGGATCATT
  CAGCTCAGCAAACAAATACAGCTGGAAGCAATGTTACTACATCATCAACTCCTAATAGTA
  ACTCTACATCTGGTTCTGCTACTAGCAACCCTTTTGGTTTAGGTGGCCTTGGGGGACTTG
  CAGGTCTGAGTAGCTTGGGTTTGAATACTACCAACTTCTCTGAACTACAGAGTCAGATGC
  AGCGACAACTTTTGTCTAACCCTGAAATGATGGTCCAGATCATGGAAAATCCCTTTGTTC
  AGAGCATGCTCTCAAATCCTGACCTGATGAGACAGTTAATTATGGCCAATCCACAAATGC
  AGCAGTTGATACAGAGAAATCCAGAAATTAGTCATATGTTGAATAATCCAGATATAATGA
  GACAAACGTTGGAACTTGCCAGGAATCCAGCAATGATGCAGGAGATGATGAGGAACCAGG
  ACCGAGCTTTGAGCAACCTAGAAAGCATCCCAGGGGGATATAATGCTTTAAGGCGCATGT
  ACACAGATATTCAGGAACCAATGCTGAGTGCTGCACAAGAGCAGTTTGGTGGTAATCCAT
  TTGCTTCCTTGGTGAGCAATACATCCTCTGGTGAAGGTAGTCAACCTTCCCGTACAGAAA
  ATAGAGATCCACTACCCAATCCATGGGCTCCACAGACTTCCCAGAGTTCATCAGCTTCCA
  GCGGCACTGCCAGCACTGTGGGTGGCACTACTGGTAGTACTGCCAGTGGCACTTCTGGGC
  AGAGTACTACTGCGCCAAATTTGGTGCCTGGAGTAGGAGCTAGTATGTTCAACACACCAG
  GAATGCAGAGCTTGTTGCAACAAATAACTGAAAACCCACAACTGATGCAAAACATGTTGT
  CTGCCCCCTACATGAGAAGCATGATGCAGTCACTAAGCCAGAATCCTGACCTTGCTGCAC
  AGATGCAGAATCCTGATACACTATCAGCAATGTCAAACCCTAGAGCAATGCAGGCCTTGT
  TACAGATTCAGCAGGGTTTACAGACATTAGCAACGGAAGCCCCGGGCCTCATCCCAGGGT
  TTACTCCTGGCTTGGGGGCATTAGGAAGCACTGGAGGCTCTTCGGGAACTAATGGATCTA
  ACGCCACACCTAGTGAAAACACAAGTCCCACAGCAGGAACCACTGAACCTGGACATCAGC
  AGTTTATTCAGCAGATGCTGCAGGCTCTTGCTGGAGTAAATCCTCAGCTACAGAATCCAG
  AAGTCAGATTTCAGCAACAACTGGAACAACTCAGTGCAATGGGATTTTTGAACCGTGAAG
  CAAACTTGCAAGCTCTAATAGCAACAGGAGGTGATATCAATGCAGCTATTGAAAGGTTAC
  TGGGCTCCCAGCCATCATAGCAGCATTTCTGTATCTTGAAAAAATGTAATTTATTTTTGA
  TAACGGCTCTTAAACTTTAAAATACCTGCTTTATTTCATTTTGACTCTTGGAATTCTGTG
  CTGTTATAAACAAACCCAATATGATGCATTTTAAGGTGGAGTACAGTAAGATGTGTGGGT
  TTTTCTGTATTTTTCTTTTCTGGAACAGTGGGAATTAAGGCTACTGCATGCATCACTTCT
  GCATTTATTGTAATTTTTTAAAAACATCACCTTTTATAGTTGGGTGACCAGATTTTGTCC
  TGCATCTGTCCAGTTTATTTGCTTTTTAAACATTAGCCTATGGTAGTAATTTATGTAGAA
  TAAAAGCATTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_053067
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_053067.1, NP_444295.1
• RefSeq Size: 2354 bp
• RefSeq ORF: 1686 bp
• Locus ID: 29979
• UniProt ID: Q9UMX0
• Cytogenetics: 9q21.2-q21.3
• Domains: UBA, UBQ, STI1
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) is missing an alternate 3' coding exon, compared to transcript variant 1. The resulting protein (isoform 2) is 28 aa shorter when compared to isoform 1.