NKG2A (KLRC1) (NM_213658) Human Untagged Clone

CAT#: SC125810

KLRC1 (untagged)-Human killer cell lectin-like receptor subfamily C, member 1 (KLRC1), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NKG2A
• Synonyms: CD159A; NKG2; NKG2A
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_213658 edited
  GGCAAGCACAGGAGGATGGGTCCCTTTTCAGGTCTGGAGATGGAATCACTGTTGCTATAG
  CAGGCCTTTTTATGAGACTAACCTGGCCTCTCCACTAAAGGATGTGTGACTTTCTGGGGA
  CAGAAGAGTACAGTCCCTGACATCACACACTGCAGAGATGGATAACCAAGGAGTAATCTA
  CTCAGACCTGAATCTGCCCCCAAACCCAAAGAGGCAGCAACGAAAACCTAAAGGCAATAA
  AAGCTCCATTTTAGCAACTGAACAGGAAATAACCTATGCGGAATTAAACCTTCAAAAAGC
  TTCTCAGGATTTTCAAGGGAATGACAAAACCTATCACTGCAAAGATTTACCATCAGCTCC
  AGAGAAGCTCATTGTTGGGATCCTGGGAATTATCTGTCTTATCTTAATGGCCTCTGTGGT
  AACGATAGTTGTTATTCCCTCTACATTAATACAGAGGCACAACAATTCTTCCCTGAATAC
  AAGAACTCAGAAAGCACGTCATTGTGGCCATTGTCCTGAGGAGTGGATTACATATTCCAA
  CAGTTGTTACTACATTGGTAAGGAAAGAAGAACTTGGGAAGAGAGTTTGCTGGCCTGTAC
  TTCGAAGAACTCCAGTCTGCTTTCTATAGATAATGAAGAAGAAATGAAATTTCTGTCCAT
  CATTTCACCATCCTCATGGATTGGTGTGTTTCGTAACAGCAGTCATCATCCATGGGTGAC
  AATGAATGGTTTGGCTTTCAAACATGAGATAAAAGACTCAGATAATGCTGAACTTAACTG
  TGCAGTGCTACAAGTAAATCGACTTAAATCAGCCCAGTGTGGATCTTCAATAATATATCA
  TTGTAAGCATAAGCTTTAGAGGTAAAGCGTTTGCATTTGCAGTGCATCAGATAAATTGTA
  TATTTCTTAAAATAGAAATATATTATGATTGCATAAATCTTAAAATGAATTATGTTATTT
  GCTCTAATAAGAAAATTCTAAATCAATTATTGAAACAGGATACACACAATTACTAAAGTA
  CAGACATCCTAGCATTTGTGTCGGGCTCATTTTGCTCAACATGGTATTTGTGGTTTTCAG
  CCTTTCTAAAAGTTGCATGTTATGTGAGTCAGCTTATAGGAAGTACCAAGAACAGTCAAA
  CCCATGGAGACAGAAAGTAGAATAGTGGTTGCCAATGTCTGAGGGAGGTTGAAATAGGAG
  ATGACCTCTAACTGATAGAACGTTACTTTGTGTCGTGATGAAAACTTTCTAAATTTCAGT
  AGTGGTGATGGTTGTAACTCTGCGAATATACTAAACATCATTGATTTTTAATCATTTTAA
  GTGCATGAAATGTATGCTTTGTACACGACACTTCAATAAAGCTATCCAGAAAAAAAAAAA
  AAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_213658 unedited
  NNAAGTTAGGTTTTGTATACGACTCATATAGGCGGACCGCGAATTCGCACGAGGGGCAAG
  CACAGGAGGATGGGTCCCTTTTCAGGTCTGGAGATGGAATCACTGTTGCTATAGCAGGCC
  TTTTTATGAGACTAACCTGGCCTCTCCACTAAAGGATGTGTGACTTTCTGGGGACAGAAG
  AGTACAGTCCCTGACATCACACACTGCAGAGATGGATAACCAAGGAGTAATCTACTCAGA
  CCTGAATCTGCCCCCAAACCCAAAGAGGCAGCAACGAAAACCTAAAGGCAATAAAAGCTC
  CATTTTAGCAACTGAACAGGAAATAACCTATGCGGAATTAAACCTTCAAAAAGCTTCTCA
  GGATTTTCAAGGGAATGACAAAACCTATCACTGCAAAGATTTACCATCAGCTCCAGAGAA
  GCTCATTGTTGGGATCCTGGGAATTATCTGTCTTATCTTAATGGCCTCTGTGGTAACGAT
  AGTTGTTATTCCCTCTACATTAATACAGAGGCACAACAATTCTTCCCTGAATACAAGAAC
  TCAGAAAGCACGTCATTGTGGCCATTGTCCTGNAGAGTGGATTACATATTCCAACAGTTG
  TTACTACATTGGTAAGGAAAAGAGAACCTGGGAGAGAGTTTGCTGGCCTGTACTTTCGAG
  AACTCCNGTCTGCTTTCATGGNTAATGAAGAAGAATGGAATTTCTGTCTTCANTTCACCA
  TCCAAGGAATTGGGGGGTTNCAACCAACATCCTATTCAGGGTGAACAAGAAGGGTTGGCT
  TTCAACCTGGATAAAAGCTCCATAAGGGGGAACTTAACGGGCCGGGCTCCAGTAAACCGC
  CTTAAAACCCCCCGGGGGGTCTCCAAAATTTAAATGGGAACCAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_213658
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_213658.1, NP_998823.1
• RefSeq Size: 1386 bp
• RefSeq ORF: 702 bp
• Locus ID: 3821
• UniProt ID: P26715
• Cytogenetics: 12p13.2
• Protein Families: Transmembrane
• Protein Pathways: Antigen processing and presentation, Graft-versus-host disease, Natural killer cell mediated cytotoxicity
• Gene Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
  Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (NKG2-A).