DHCR7 (NM_001163817) Human 3' UTR Clone
CAT#: SC211397
3' UTR clone of 7-dehydrocholesterol reductase (DHCR7) transcript variant 2 for miRNA target validation
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Specifications
Product Data | |
Vector | pMirTarget |
Species | Human |
Transfection Reporter | RFP |
Assay Reporter | Luciferase |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Symbol | DHCR7 |
Synonyms | SLOS |
ACCN | NM_001163817 |
Insert Size | 994 bp |
Sequence Data |
>SC211397 3’UTR clone of NM_001163817
The sequence shown below is from the reference sequence of NM_001163817. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCTTACCGCCTGCTGCCTGGAATCTTCTAAGGGCACGCCCTAGGGAGAAGCCCTGTGGGGCTGTCAAGA GCGTGTTCTGCCAGGTCCATGGGGGCTGGCATCCCAGCTCCAACTCGAGGAGCCTCAGTTTCCTCATCT GTAAACTGGAGAGAGCCCAGCACTTGGCAGGTGTCCAGTACCTAATCACGCTCTGTTCCTTGCTTTTGC CTTCAAGGGAATTCCGAGTGTCCAGCACTGCCGTATTGCCAGCACAGACGGATTTTCTCTAATCAGTGT CCCTGGGGCAGGAGGATGACCCAGTCACCTTTACTAGTCCTTTGGAGACAATTTACCTGTATTAGGAGC CCAGGCCACGCTACACTCTGCCCACACTGGTGAGCAGGAGGTCTTCCCACGCCCTGTCATTAGGCTGCA TTTACTCTTGCTAAATAAAAGTGGGAGTGGGGCGTGCGCGTTATCCATGTATTGCCTTTCAGCTCTAGA TCCCCCTCCCCTGCCTGCTCTGCAGTCGTGGGTGGGGCCCGTGCGCCGTTTCTCCTTGGTAGCGTGCAC GGTGTTGAACTGGGACACTGGGGAGAAAGGGGCTTTCATGTCGTTTCCTTCCTGCTCCTGCTGCACAGC TGCCAGGAGTGCTCTGCCTGGAGTCTGCAGACCTCAGAGAGGTCCCAGCACCGGCTGTGGCCTTTCAGG TGTAGGCAGGTGGGCTCTGCTTCCCGATTCCCTGTGAGCGCCCACCCTCTCGAAAGAATTTTCTGCTTG CCCTATGACTGTGCAGACTCTGGCTCGAGCAACCCGGGGAACTTCACCCTCAGGGGCCTCCCACACCTT CTCCAGCGAGGAGGTCTCAGTCCCAGCCTCGGGAGGGCACCTCCTTTTCTGTGCTTTCTTCCCTGAGGC ATTCTTCCTCATCCCTAGGGTGTTGTGTAGAACTCTTTTTAAACTCTATGCTCCGAGTAGAGTTCATCT TTATATTAAACTTCCCCTGTTCAAATAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. |
Reference Data | |
RefSeq | NM_001163817.2 |
Summary | This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009] |
Locus ID | 1717 |
MW | 36.1 |
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