Glucocorticoid Receptor (NR3C1) Mouse Monoclonal Antibody [Clone ID: OTI2C4]
CAT#: TA806187
NR3C1 mouse monoclonal antibody, clone OTI2C4 (formerly 2C4)
Size: 30 ul
Formulation: Carrier-Free
Specifications
Product Data | |
Clone Name | OTI2C4 |
Applications | IHC, WB |
Recommended Dilution | WB 1:2000, IHC 1:150 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 1-265 of human NR3C1(NP_000167) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 85.5 kDa |
Gene Name | nuclear receptor subfamily 3 group C member 1 |
Database Link | |
Background | This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] |
Synonyms | GCCR; GCR; GCRST; GR; GRL |
Reference Data | |
Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
Protein Pathways | Neuroactive ligand-receptor interaction |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF806187 | Carrier-free (BSA/glycerol-free) NR3C1 mouse monoclonal antibody, clone OTI2C4 (formerly 2C4) |
USD 600.00 |
|
TA806187AM | NR3C1 mouse monoclonal antibody, clone OTI2C4 (formerly 2C4), Biotinylated |
USD 509.00 |
|
TA806187BM | NR3C1 mouse monoclonal antibody, clone OTI2C4 (formerly 2C4), HRP conjugated |
USD 509.00 |
|
TA806187S | NR3C1 mouse monoclonal antibody, clone OTI2C4 (formerly 2C4) |
USD 200.00 |
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