p16INK4A (CDKN2A) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI5H5]
CAT#: TA805237AM
CDKN2A (p16INK4a) mouse monoclonal antibody, clone OTI5H5 (formerly 5H5), Biotinylated
Conjugation: Unconjugated HRP
USD 867.00
USD 436.00
Specifications
Product Data | |
Clone Name | OTI5H5 |
Applications | IHC, WB |
Recommended Dilution | WB 1:200 - 1:1000, IHC 1:150 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human CDKN2A (NP_000068) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Biotin |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 16.4 kDa |
Gene Name | cyclin-dependent kinase inhibitor 2A |
Database Link | |
Background | This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012] |
Synonyms | ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF805237 | Carrier-free (BSA/glycerol-free) CDKN2A mouse monoclonal antibody, clone OTI5H5 (formerly 5H5) |
USD 600.00 |
|
TA805237 | CDKN2A (p16INK4a) mouse monoclonal antibody, clone OTI5H5 (formerly 5H5) |
USD 447.00 |
|
TA805237BM | CDKN2A (p16INK4a) mouse monoclonal antibody, clone OTI5H5 (formerly 5H5), HRP conjugated |
USD 509.00 |
|
TA805237S | CDKN2A (p16INK4a) mouse monoclonal antibody, clone OTI5H5 (formerly 5H5) |
USD 200.00 |
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