FEN1 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1F3]
CAT#: TA802762BM
FEN1 mouse monoclonal antibody,clone 1F3, HRP conjugated
Conjugation: Unconjugated Biotin
USD 867.00
USD 436.00
Specifications
Product Data | |
Clone Name | OTI1F3 |
Applications | IHC, WB |
Recommended Dilution | WB 1:2000, IHC 1:150 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 117-380 of human FEN1 (NP_004102) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | HRP |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 42.4 kDa |
Gene Name | flap structure-specific endonuclease 1 |
Database Link | |
Background | The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008] |
Synonyms | FEN-1; MF1; RAD2 |
Reference Data | |
Protein Families | Druggable Genome, Stem cell - Pluripotency |
Protein Pathways | Base excision repair, DNA replication, Non-homologous end-joining |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF802762 | Carrier-free (BSA/glycerol-free) FEN1 mouse monoclonal antibody, clone OTI1F3 (formerly 1F3) |
USD 600.00 |
|
TA802762 | FEN1 mouse monoclonal antibody, clone OTI1F3 (formerly 1F3) |
USD 447.00 |
|
TA802762AM | FEN1 mouse monoclonal antibody,clone 1F3, Biotinylated |
USD 509.00 |
|
TA802762S | FEN1 mouse monoclonal antibody, clone OTI1F3 (formerly 1F3) |
USD 200.00 |
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