SF3A1 Mouse Monoclonal Antibody [Clone ID: OTI4D8]
USD 867.00
USD 436.00
Specifications
Product Data | |
Clone Name | OTI4D8 |
Applications | IHC, WB |
Recommended Dilution | WB 1:2000, IHC 1:500 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 249-568 of human SF3A1 (NP_005868) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 88.7 kDa |
Gene Name | splicing factor 3a subunit 1 |
Database Link | |
Background | This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
Synonyms | PRP21; PRPF21; SAP114; SF3A120 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Spliceosome |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF800588 | Carrier-free (BSA/glycerol-free) SF3A1 mouse monoclonal antibody, clone OTI4D8 (formerly 4D8) |
USD 600.00 |
|
TA800588 | SF3A1 mouse monoclonal antibody, clone OTI4D8 (formerly 4D8) |
USD 447.00 |
|
TA800588AM | SF3A1 mouse monoclonal antibody,clone 4D8, Biotinylated |
USD 509.00 |
|
TA800588BM | SF3A1 mouse monoclonal antibody,clone 4D8, HRP conjugated |
USD 509.00 |
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