Cullin 4B (CUL4B) Rabbit Polyclonal Antibody

CAT#: TA590752

Rabbit Polyclonal CUL4B Antibody

Product Images

ELISA: CUL4B Antibody

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  Immunohistochemical staining of human esophagus shows nuclear positivity in squamous epithelial cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.

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  Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

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  Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

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  Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

• Immunohistochemical staining of paraffin-embedded Human thyroid tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

• Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752)

• Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 11; Lane 2: RT-4; Lane 3: U-251 MG; Lane 4: Human Plasma; Lane 5: Liver; Lane 6: TonsilThis validation was performed by Protein Atlas and the presentation of data is for informational purposes only.

• HEK293T cells were transfected with the pCMV6-ENTRY control (Cat# PS100001, Left lane) or pCMV6-ENTRY CUL4B (Cat# RC220405, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CUL4B(Cat# TA590752).

• Immunofluorescent staining of human cell line U-2 OS shows no positivity.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.

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Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: WB 1:20000, IHC 1:150,ELISA 1:100-1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DNA immunization. This antibody is specific for the C Terminus Region of the target protein.
• Formulation: 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
• Concentration: 1.2mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cullin 4B
• Database Link:
  NP_001073341
  Entrez Gene 8450 Human
  UniProt ID Q13620
• Background: This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
• Synonyms: CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2
• Note: This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

• Protein Pathways: Nucleotide excision repair, Ubiquitin mediated proteolysis