SMAD1 Mouse Monoclonal Antibody [Clone ID: OTI1C2]
USD 867.00
USD 436.00
Specifications
Product Data | |
Clone Name | OTI1C2 |
Applications | IHC, WB |
Recommended Dilution | WB 1:4000, IHC 1:150 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human SMAD1(NP_001003688) produced in HEK293T cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 52.1 kDa |
Gene Name | SMAD family member 1 |
Database Link | |
Background | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] |
Synonyms | BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1 |
Reference Data | |
Protein Families | Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors |
Protein Pathways | TGF-beta signaling pathway |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF507243 | Carrier-free (BSA/glycerol-free) SMAD1 mouse monoclonal antibody, clone OTI1C2 (formerly 1C2) |
USD 600.00 |
|
TA507243 | SMAD1 mouse monoclonal antibody, clone OTI1C2 (formerly 1C2) |
USD 224.00 |
|
TA507243AM | SMAD1 mouse monoclonal antibody, clone OTI1C2 (formerly 1C2), Biotinylated |
USD 509.00 |
|
TA507243BM | SMAD1 mouse monoclonal antibody, clone OTI1C2 (formerly 1C2), HRP conjugated |
USD 509.00 |
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