CCM2 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1D1]
CAT#: TA503419AM
CCM2 mouse monoclonal antibody, clone OTI1D1 (formerly 1D1), Biotinylated
Conjugation: Unconjugated HRP
USD 867.00
USD 436.00
Specifications
Product Data | |
Clone Name | OTI1D1 |
Applications | WB |
Recommended Dilution | WB 1:2000 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Biotin |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 48.7 kDa |
Gene Name | CCM2 scaffold protein |
Database Link | |
Background | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms | C7orf22; OSM; PP10187 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF503419 | Carrier-free (BSA/glycerol-free) CCM2 mouse monoclonal antibody, clone OTI1D1 (formerly 1D1) |
USD 600.00 |
|
TA503419 | CCM2 mouse monoclonal antibody, clone OTI1D1 (formerly 1D1) |
USD 447.00 |
|
TA503419BM | CCM2 mouse monoclonal antibody, clone OTI1D1 (formerly 1D1), HRP conjugated |
USD 509.00 |
|
TA503419S | CCM2 mouse monoclonal antibody, clone OTI1D1 (formerly 1D1) |
USD 200.00 |
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