Junctional Adhesion Molecule 1 (F11R) Rabbit Polyclonal Antibody

CAT#: TA392434

CD321 polyclonal antibody

Product Images

Western blot (WB) analysis of CD321 polyclonal antibody at 1:2000 dilution Lane1:HEK293T whole cell lysate(30ug) Lane2:A549 whole cell lysate(30ug) Lane3:HepG2 whole cell lysate(30ug)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:2000~1:5000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CD321.
• Specificity: CD321 polyclonal antibody detects endogenous levels of CD321 protein.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 38 kDa
• Gene Name: F11 receptor
• Database Link:
  Entrez Gene 50848 Human
  UniProt ID Q9Y624
• Background: Junctional Adhesion Molecule-A/F11 Receptor (JAM-A/F11R) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. JAM-A regulates multiple cellular processes, including tight junction assembly, epithelial-mesenchymal transition (EMT), leukocyte migration, virus binding, platelet activation, and angiogenesis. Aberrant expression of JAM-A is correlated with poor patient prognosis in several human cancers. In a mouse model of atherosclerosis, an antagonistic peptide that inhibits JAM-A-expressing platelets from interacting with inflamed endothelial cells reduces atherosclerotic plaque formation.
• Synonyms: CD_antigen: CD321; F11R; JAM-1; JAM-A; JAM1; JCAM; Junctional adhesion molecule 1; Junctional adhesion molecule A; PAM-1; Platelet adhesion molecule 1; Platelet F11 receptor; UNQ264/PRO301
• Note: For research use only, not for use in diagnostic procedure.