HEXIM1 Rabbit Polyclonal Antibody
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Other products for "HEXIM1"
Specifications
Product Data | |
Applications | ELISA, IF, IHC, WB |
Recommended Dilution | WB: 1/500-1/2000 IHC: 1/100-1/300 IF: 1/200-1/1000 ELISA: 1/10000 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230 |
Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
Concentration | lot specific |
Purification | Affinity Chromatography |
Conjugation | Unconjugated |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Stability | 1 year |
Predicted Protein Size | Observed MW (kDa):40 |
Gene Name | hexamethylene bis-acetamide inducible 1 |
Database Link | |
Background | Swiss-Prot Acc.O94992.Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). |
Synonyms | CLP-1; CLP1; EDG1; FLJ13562; HIS1; HMBA-inducible; MAQ1 |
Reference Data |
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