Calcium Sensing Receptor (CASR) Rabbit Polyclonal Antibody

CAT#: TA363616

CASR Antibody - middle region

Product Images

Host: Rabbit Target Name: CASR Sample Tissue: Human 786-0 Whole Cell lysates Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle terminal region of human CASR
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 119 kDa
• Gene Name: calcium sensing receptor
• Database Link:
  NP_000379.2
  Entrez Gene 846 Human
  UniProt ID P41180-2
• Background: The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
• Synonyms: CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; MGC138441; NSHPT; PCAR1

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane