G0 Protein alpha (GNAO1) Rabbit Polyclonal Antibody

CAT#: TA332531

Rabbit anti-GNAO1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using GNAO1 antibody.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human GNAO1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 354
• Gene Name: G protein subunit alpha o1
• Database Link:
  NP_066268
  Entrez Gene 14681 MouseEntrez Gene 50664 RatEntrez Gene 2775 Human
  UniProt ID P09471
• Background: Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.
• Synonyms: EIEE17; G-ALPHA-o; GNAO; HLA-DQB1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Long-term depression, Melanogenesis