Cullin 3 (CUL3) Goat Polyclonal Antibody
Frequently bought together (3)
Transient overexpression lysate of cullin 3 (CUL3)
USD 436.00
Other products for "Cullin 3"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB: 1-3ug/ml, ELISA: 1:2,000 |
Reactivities | Human (Expected from sequence similarity: Mouse, Rat) |
Host | Goat |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Internal region (AQVTGSNTRKHILQ) |
Formulation | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
Concentration | lot specific |
Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | cullin 3 |
Database Link | |
Background | Cullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various physiological processes (1). Cullin 3-based E3 ligase (CUL3) forms a catalytically inactive BTB-CUL3-Rbx1 (BCR) ubiquitin ligase, which becomes functional upon covalent attachment of the ubiquitin Nedd8 (neural precursor cell-expressed, developmentally downregulated 8) near the C terminus of CUL3 (2). CUL3 plays an essential role in both axonal arborization and proper elaboration of dendrites and may require neddylation for its proper function (3). The CUL3 pathway, which selects cyclin E for ubiquitination on the basis of its assembly into CDK complexes, may be one way to control cyclin abundance (4). In a complex with the substrate-specific adaptors KLHL9 and KLHL13, CUL3 is required for correct chromosome alignment in metaphase, proper midzone and midbody formation, and completion of cytokinesis (5). |
Synonyms | CUL-3; PHA2E |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Ubiquitin mediated proteolysis |
Documents
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FAQs |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
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