hnRNP A2B1 (HNRNPA2B1) Rabbit Polyclonal Antibody
Frequently bought together (3)
Transient overexpression lysate of heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), transcript variant A2
USD 436.00
Recombinant protein of human heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), transcript variant A2, 20 µg
USD 867.00
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Specifications
Product Data | |
Applications | ICC/IF, IHC, WB |
Recommended Dilution | WB 1:500 - 1:2000;IF 1:50- 1:200 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human HNRNPA2B1 |
Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | heterogeneous nuclear ribonucleoprotein A2/B1 |
Database Link | |
Background | Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts . Alternative splicing produces transcripts that encode two homologous hnRNP proteins, hnRNPA2 and hnRNPB1, from a single gene sequence . Studies demonstrate hnRNP A2/B1 splicing repression across multiple targets and that both proteins can bind and protect telomere repeat sequences from DNase digestion . Altered expression of hnRNP B1 is seen in several forms of cancer, including squamous cell carcinoma, adenocarcinoma, and various forms of lung cancer . Over expression of hnRNP B1 may be associated with inhibition of DNA-PK activity and impaired DNA repair during early stages of cancer development . Autoantigens to hnRNP A2/B1 (termed RA33) are associated with rheumatoid arthritis, systemic lupus erythromatosus and mixed connective tissue disease. |
Synonyms | HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1 |
Reference Data | |
Protein Families | Druggable Genome |
Documents
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