hnRNP A2B1 (HNRNPA2B1) Rabbit Polyclonal Antibody

CAT#: TA326961

HNRNPA2B1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using HNRNPA2B1 antibody.

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  Immunofluorescence analysis of HeLa cell using HNRNPA2B1 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human HNRNPA2B1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: heterogeneous nuclear ribonucleoprotein A2/B1
• Database Link:
  NP_002128
  Entrez Gene 53379 MouseEntrez Gene 362361 RatEntrez Gene 3181 Human
  UniProt ID P22626
• Background: Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts . Alternative splicing produces transcripts that encode two homologous hnRNP proteins, hnRNPA2 and hnRNPB1, from a single gene sequence . Studies demonstrate hnRNP A2/B1 splicing repression across multiple targets and that both proteins can bind and protect telomere repeat sequences from DNase digestion . Altered expression of hnRNP B1 is seen in several forms of cancer, including squamous cell carcinoma, adenocarcinoma, and various forms of lung cancer . Over expression of hnRNP B1 may be associated with inhibition of DNA-PK activity and impaired DNA repair during early stages of cancer development . Autoantigens to hnRNP A2/B1 (termed RA33) are associated with rheumatoid arthritis, systemic lupus erythromatosus and mixed connective tissue disease.
• Synonyms: HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1

Reference Data

• Protein Families: Druggable Genome