IL28B (IFNL3) Rabbit Polyclonal Antibody

CAT#: TA326656

Rabbit Polyclonal IL-28B Antibody

Product Images

Western blot analysis of IL-28B in HeLa cell lysate with IL-28B antibody at (A) 1 and (B) 2 ug/ml.

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  Immunofluorescence of IL-28B in HeLa cells with IL-28B antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-28B antibody was raised against a 17 amino acid peptide near the center of human IL-28B.
• Formulation: IL-28B Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IL-28B Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 20 kDa; Observed: 16 kDa
• Gene Name: interferon, lambda 3
• Database Link:
  NP_742151
  Entrez Gene 282617 Human
  UniProt ID Q8IZI9
• Background: Interleukin 28 (IL-28B), also known as interferon lambda 3, is cytokine distantly related to type I interferons and the IL-10 family (1). The IL-28B gene and the closely related cytokine genes IL-28A and IL-29 form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection and can induce anti-viral activity (2,3). All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor-beta (IL10RB) and interleukin 28 receptor- alpha (IL28RA) (1).
• Synonyms: IL-28B; IL28B; IL28C

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway