SYK Rabbit Polyclonal Antibody
Frequently bought together (3)
Transient overexpression lysate of spleen tyrosine kinase (SYK), transcript variant 1
USD 436.00
Recombinant protein of human spleen tyrosine kinase (SYK), transcript variant 1, 20 µg
USD 867.00
Other products for "SYK"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:200 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | A synthesized peptide derived from human SYK |
Formulation | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Concentration | lot specific |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | spleen tyrosine kinase |
Database Link | |
Background | The Src-related protein tyrosine kinases Lck p56 and Fyn p59 are critically involved in T cell antigen receptor (TCR)/CD3-triggered activation. T lymphocytes also express a second class of non-receptor protein tyrosine kinases which includes Syk p70 and ZAP p72. These kinases resemble the Src family protein tyrosine kinases in that they have a C-terminal catalytic domain, but differ in that they are characterized by two SH2 domains but no SH3 domains. Evidence for the involvement of the Syk/ZAP family proteins in T cell activation was suggested by the finding that Syk p72 kinase fused to the transmembrane and extracellular domains of CD7 and DC16, respectively, can induce complete T cell activation. In contrast, the ZAP p70 kinase was insufficient unless it was coaggregated with a Fyn p59-containing chimera,suggesting that regulation of ZAP p70 activity may require a functional interaction with Src family kinases. |
Synonyms | p72-Syk |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity |
Documents
Product Manuals |
FAQs |
SDS |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.