DEP1 (PTPRJ) Rabbit Polyclonal Antibody

CAT#: TA322944

Anti-PTPRJ Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA322944 (PTPRJ Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA322944 (PTPRJ Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322944 (PTPRJ Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322944 (PTPRJ Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 1323-1337 amino acids of Human protein tyrosine phosphatase, receptor type, J
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protein tyrosine phosphatase, receptor type J
• Database Link:
  NP_002834
  Entrez Gene 19271 MouseEntrez Gene 5795 Human
  UniProt ID Q12913
• Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes; including cell growth; differentiation; mitotic cycle; and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats; a single transmembrane region; and a single intracytoplasmic catalytic domain; and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages; and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor; and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: CD148; DEP1; HPTPeta; R-PTP-ETA; SCC1

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Transmembrane
• Protein Pathways: Adherens junction