TIMP2 Rabbit Polyclonal Antibody

CAT#: TA322881

Anti-TIMP2 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322881 (TIMP2 Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322881 (TIMP2 Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA322881 (TIMP2 Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA322881 (TIMP2 Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 30-220 amino acids of human TIMP metallopeptidase inhibitor 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TIMP metallopeptidase inhibitor 2
• Database Link:
  NP_003246
  Entrez Gene 21858 MouseEntrez Gene 29543 RatEntrez Gene 7077 Human
  UniProt ID P16035
• Background: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases; a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases; the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result; the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors; and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
• Synonyms: CSC-21K; DDC8

Reference Data

• Protein Families: Druggable Genome, Secreted Protein