CMPK2 Rabbit Polyclonal Antibody

CAT#: TA320098

Rabbit Polyclonal CMPK2 Antibody

Product Images

Western blot analysis of CMPK2 in rat lung tissue lysate with CMPK2 antibody at 1 ug/mL

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  Immunofluorescence of CMPK2 in human lung tissue with CMPK2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 ug/ml.
  IF on FFPE tissues: 20 ug/ml.
  All other applications and species have not yet been tested.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CMPK2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human CMPK2.
• Formulation: CMPK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CMPK2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 49 kDa
• Gene Name: cytidine/uridine monophosphate kinase 2
• Database Link:
  NP_997198
  Entrez Gene 22169 MouseEntrez Gene 314004 RatEntrez Gene 129607 Human
  UniProt ID Q5EBM0
• Background: CMPK2 Antibody: UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response
• Synonyms: NDK; TMPK2; TYKi; UMP-CMPK2

Reference Data

• Protein Pathways: Metabolic pathways, Pyrimidine metabolism