PAPP A2 (PAPPA2) Rabbit Polyclonal Antibody

CAT#: TA319996

Rabbit Polyclonal PLAC3 Antibody

Product Images

Western blot analysis of PLAC3 in HeLa cell lysate with PLAC3 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of PLAC3 in HeLa cells with PLAC3 antibody at 20 ug/mL.

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  Immunocytochemistry of PLAC3 in HeLa cells with PLAC3 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PLAC3 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human PLAC3.
• Formulation: PLAC3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: PLAC3 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: pappalysin 2
• Database Link:
  NP_064714
  Entrez Gene 23850 MouseEntrez Gene 680415 RatEntrez Gene 364027 RatEntrez Gene 60676 Human
  UniProt ID Q9BXP8
• Background: PLAC3 Antibody: PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
• Synonyms: PAPP-A2; PAPP-E; PAPPE; PLAC3

Reference Data

• Protein Families: Protease, Secreted Protein