TAPA1 (CD81) Rabbit Polyclonal Antibody

CAT#: TA306789

Rabbit Polyclonal CD81 Antibody

Product Images

Western blot analysis of CD81 in human lung tissue lysate with CD81 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking petide.

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  Immunohistochemistry of CD81 in human lung tissue with CD81 antibody at 5 ug/ml.

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  Immunofluorescence of CD81 in A549 cells with CD81 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CD81 antibody was raised against a 20 amino acid peptide near the amino terminus of human CD81.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD81 molecule
• Database Link:
  NP_004347
  Entrez Gene 12520 MouseEntrez Gene 25621 RatEntrez Gene 975 Human
  UniProt ID P60033
• Background: CD81 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family, a group of cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that associates with integrins and appears to promote muscle cell fusion and support myotube maintenance. Along with SCARB1, LDL-R, and CLDN1, CD81 has been reported to be an entry factor for the Hepatitis C virus. Finally, recent evidence indicates that the CD81 gene is localized in a tumor-suppressor gene region and is thus a candidate gene for malignancies.
• Synonyms: CVID6; S5.7; TAPA1; TSPAN28

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: B cell receptor signaling pathway