RSK1 p90 (RPS6KA1) Rabbit Polyclonal Antibody

CAT#: TA306221

Rabbit Polyclonal RPS6K1 Antibody

Product Images

Western blot analysis of RPS6K1 in Jurkat cell lysate with RPS6K1 antibody at (A) 2.5, (B) 5 and (C) 10 ug/mL.

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  Immunofluorescence of RP S6 Kinase in Jurkat cells with RP S6 Kinase antibody at 20 ug/mL.

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  Immunocytochemistry of RPS6K1 in Jurkat cells with RPS6K1 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 2.5 - 10 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RPS6K1 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human RPS6K1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ribosomal protein S6 kinase A1
• Database Link:
  AAC82497
  Entrez Gene 6195 Human
  UniProt ID Q15418
• Background: Ribosomal protein S6 kinase 1 (RPS6K1) is the best characterized effector of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (1,2). Nutrients and growth factors stimulate a complex including TOR, raptor (regulatory associated protein of TOR), and G?L to phosphorylate RPS6K1 and the eukaryotic initiation factor 4E binding protein (4EBP1), leading to increased protein synthesis and cell growth (3). RPS6K1 is thought to desensitize tissues to insulin as mice deficient in RPS6K1 have been shown to be hypersensitive to insulin and impervious to obesity-induced insulin resistance seen in wild type obese mice (4).
• Synonyms: HU-1; MAPKAPK1A; p90Rsk; RSK; RSK1