CERK Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | ICC/IF, WB |
Recommended Dilution | Immunocytochemistry/ Immunofluorescence: 1:500-1:2000, Western Blot: 2 ug/ml |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | A synthetic peptide made to an internal portion of the human ceramide kinase protein sequence (between residues 50-150). [Swiss-Prot Q8TCT0] |
Formulation | Tris-glycine, 150mM NaCl and 0.05% sodium azide |
Concentration | lot specific |
Purification | peptide affinity purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | ceramide kinase |
Database Link | |
Background | Ceramide kinase (CERK) is a novel lipid kinase. It is responsible for catalyzing the phosphorylation that produces a signaling lipid called ceramide-1-phosphate (C1P). C1P is an important biological mediator that induces inflammatory pathways such as those blocked by many allergy medications. Findings suggest that CERK could be a novel target for a new generation of anti-inflammatory/anti-trauma therapeutics dealing with such conditions as arthritis, asthma, multiple sclerosis, lung and colon cancers and Alzheimer's disease. |
Synonyms | dA59H18.2; dA59H18.3; hCERK; LK4 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Metabolic pathways, Sphingolipid metabolism |
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