Insulin (INS) Mouse Monoclonal Antibody [Clone ID: K36aC10]

CAT#: DM234

Insulin (INS) mouse monoclonal antibody, clone K36aC10, Ascites

Specifications

Product Data

• Clone Name: K36aC10
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin/Paraffin Sections: Use a dilution of 1/25-1/50 in an ABC method (30 minutes at room temperature).
  Recommended Positive Control: Pancreas.
• Reactivities: Bovine, Canine, Equine, Feline, Guinea Pig, Human, Porcine, Rabbit, Rat, Sheep
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human Insulin.
• Specificity: This antibody recognizes purified Insulin from the pancreas of Human, Bovine, Horse, Sheep as well as Proinsulin from Human.
  Cross reaction has been observed with insulin containing cells in fixed sections of pancreas from Human, Porcine, Dog, Rabbit, Bovine, Sheep, Rat, Guinea Pig and Cat.
  Cellular Localization: Cytoplasmic.
• Formulation: State: Ascites
  State: Diluted Ascites
  Preservative: < 0.1% Sodium Azide
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Gene Name: insulin
• Database Link:
  Entrez Gene 3630 Human
  UniProt ID P01308
• Background: Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.
• Synonyms: INS