Constitutive androstane receptor (NR1I3) Mouse Monoclonal Antibody [Clone ID: OTI9E1]
CAT#: CF805366
Carrier-free (BSA/glycerol-free) NR1I3 mouse monoclonal antibody, clone OTI9E1 (formerly 9E1)
Formulation: Standard
Specifications
Product Data | |
Clone Name | OTI9E1 |
Applications | WB |
Recommended Dilution | WB 1:2000 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 1-236 of human NR1I3 (NP_001070950) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 40.3 kDa |
Gene Name | nuclear receptor subfamily 1 group I member 3 |
Database Link | |
Background | This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Synonyms | CAR; CAR1; MB67 |
Reference Data | |
Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA805366 | NR1I3 mouse monoclonal antibody, clone OTI9E1 (formerly 9E1) |
USD 447.00 |
|
TA805366AM | NR1I3 mouse monoclonal antibody, clone OTI9E1 (formerly 9E1), Biotinylated |
USD 509.00 |
|
TA805366BM | NR1I3 mouse monoclonal antibody, clone OTI9E1 (formerly 9E1), HRP conjugated |
USD 509.00 |
|
TA805366S | NR1I3 mouse monoclonal antibody, clone OTI9E1 (formerly 9E1) |
USD 200.00 |
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