TdT (DNTT) (C-term) Rabbit Polyclonal Antibody

CAT#: AP54213PU-N

TdT (DNTT) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

TdT Antibody (C-term) western blot analysis in K562 cell line lysates (35 ug/lane). This demonstrates the TdT antibody detected the TdT protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:1;000.
  Western blot: 1:100~500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 445-475 amino acids from the C-terminal region of human TdT
• Specificity: This antibody detects DNTT / TDT (C-term).
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: DNA nucleotidylexotransferase
• Database Link:
  Entrez Gene 1791 Human
  UniProt ID P04053
• Background: This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
• Synonyms: DNA nucleotidylexotransferase
• Note: Molecular Weight: 58536 Da

Reference Data

• Protein Pathways: Hematopoietic cell lineage, Non-homologous end-joining