Histone H2A.X (H2AFX) pSer139 Rabbit Polyclonal Antibody
CAT#: AP20846PU-N
Histone H2A.X (H2AFX) pSer139 rabbit polyclonal antibody, Aff - Purified
Other products for "Histone H2A.X"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of Histone H2A.X protein only when phophorylated at Serine 139. |
Formulation | Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). Preservative: 0.05% Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen. |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~ 15 kDa |
Gene Name | H2A histone family member X |
Database Link | |
Background | Histone H2A.X is a member of the Histone H2A family, which is involved in nucleosomal organization of chromatin. The Histone H2A.X gene is located in close proximity to the porphobilinogen deaminase (PBGD) gene in both mouse and human, and maps to 9 A5.2 and 11q23.3, respectively. H2A.X differs from the other members of the H2A family by the presence of a highly conserved C-terminal motif. It is rapidly phosphorylated in response to ionizing radiation and plays an important role in the recognition and repair of DNA double stranded breaks. The phosphorylated form of H2A.X, designated γ-H2A.X, forms nuclear foci at the heavy chain constant region of cells involved in class switch recombination (CSR), a region-specific DNA reaction that replaces one immunoglobulin heavy chain constant region gene with another. The phosphorylated gamma-H2A.X is also thought to initiate subsequent repair factors, including Rad50, Rad51 and BRCA1. |
Synonyms | H2a/x, H2AFX, H2AX |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Systemic lupus erythematosus |
Documents
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