Aquaporin 2 (AQP2) (N-term) Rabbit Polyclonal Antibody

CAT#: AP08304PU-N

Aquaporin 2 (AQP2) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Kidney: Formalin-Fixed Paraffin Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1 µg/ml.
  Immunohistochemistry on Paraffin Sections: 20 µg/ml.
  Western Blot: 1 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to N-terminal residues of Human Aquaporin 2.
• Specificity: This antibody recognizes Aquaporin 2 (N-term).
• Formulation: PBS containing 0.01% Sodium Azide as preservative and 50% Glycerol as stabilizer.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: aquaporin 2
• Database Link:
  Entrez Gene 359 Human
  UniProt ID P41181
• Background: Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein aquaporins. Aquaporin 0, and Aquaporin 1 have been the foundation of the growing family of aquaporins. The lens specific Aquaporin 0 represents up to 80% of total lens membrane protein. Defects in Aquaporin 0 are a cause of autosomal dominant cataract. The lens opacity mutation is an AA substitution that inhibits targeting of MIP to the cell membrane. Human Aquaporin 0 is a 263 amino acid transmembrane protein belonging to the MIP family. Aquaporin families of proteins are predicted to contain six transmembrane domains. The N and C terminus are predicted to be cytoplasmic. Aquaporin 2 is located in the collecting tubule.
• Synonyms: Aquaporin-CD, AQP-CD, WCH-CD
• Note: Predicted Molecular Weight: 29 kDa.