TIM 4 (TIMD4) Rabbit Polyclonal Antibody

CAT#: AP07785PU-N

TIM 4 (TIMD4) rabbit polyclonal antibody, Purified

Product Images

Figure 1. Staining TIM4 in Thymus tissue by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide -KLH conjugated corresponding to 15 amino acid peptide from near the carboxy terminus of Human TIM-4.
• Formulation: Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Dilute only prior to immediate use.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: T-cell immunoglobulin and mucin domain containing 4
• Database Link:
  Entrez Gene 91937 Human
  UniProt ID Q96H15
• Background: The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. Studies have shown that TIM 4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM 1, and that this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM 4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain (Kuchroo et al, 2003). The TIM 4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM 1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma (Shakhov et al 2004).
• Synonyms: TIMD-4, TIM4, TIM-4, T-cell membrane protein 4