CD11b (ITGAM) Mouse Monoclonal Antibody [Clone ID: BEAR-1]
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Specifications
Product Data | |
Clone Name | BEAR-1 |
Applications | IF, IHC, IP |
Recommended Dilution | Fluorescence Microscopy or Flow Cytometry (2 µg / 5x105 cells/test). Immunoprecipitation. Immunohistochemistry on Frozen Sections. Typical Starting Dilution: 1/10. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Specificity | This antibody clone Bear-1 reacts with the CD11b alpha chain of the CD11b/CD18 (p165, 95) integrin heterodimer complex present on Human NK cells, monocytes, and granulocytes. The recognized structure is the alpha chain of a heterodimer glycoprotein of Mw 165kD (alpha chain) and 95kD (beta chain). |
Formulation | PBS State: Purified State: Liquid (0.2 µm filtered) purified IgG fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein G |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C. |
Stability | Shelf life: one year from despatch. |
Gene Name | integrin subunit alpha M |
Database Link | |
Background | CD11b is an alpha chain integrin that is expressed as heterodimer noncovalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN extravasation to sites of inflammation. CD11b/CD18 interacts with both matrix and cell surface proteins including the complement component iC3b, extracellular matrix proteins and the third extracellular domain of CD54. CD11b is expressed on human NK-cells, monocytes, granulocytes, T-cells, B-cells and dendritic cells. After activation the expression is upregulated. |
Synonyms | ITGAM, CR3A, CR-3 alpha chain, Integrin alpha-M, MAC1 |
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