SAMHD1 Human Gene Knockout Kit (CRISPR)

CAT#: KN206013RB

SAMHD1 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Donor DNA: RFP-BSD
• Symbol: SAMHD1
• Locus ID: 25939
• Components:

  KN206013G1, SAMHD1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN206013G2, SAMHD1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN206013RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_015474, NM_001363729, NM_001363733
• UniProt ID: Q9Y3Z3
• Synonyms: CHBL2; DCIP; HDDC1; MOP-5; SBBI88
• Summary: This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]