Mouse Abcb8 activation kit by CRISPRa

CAT#: GA209959

Abcb8 CRISPRa kit - CRISPR gene activation of mouse ATP-binding cassette, sub-family B (MDR/TAP), member 8

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Abcb8
• Locus ID: 74610
• Kit Components:

  GA209959G1, Abcb8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA209959G2, Abcb8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA209959G3, Abcb8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_029020
• UniProt ID: Q9CXJ4
• Synonyms: 4833412N02Rik; AA409895
• Summary: ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane (By similarity). Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport (PubMed:22375032). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (PubMed:22375032).[UniProtKB/Swiss-Prot Function]