Mouse Wnt2 activation kit by CRISPRa

CAT#: GA204636

Wnt2 CRISPRa kit - CRISPR gene activation of mouse wingless-type MMTV integration site family, member 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Wnt2
• Locus ID: 22413
• Kit Components:

  GA204636G1, Wnt2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204636G2, Wnt2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204636G3, Wnt2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_023653
• UniProt ID: P21552
• Synonyms: 2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2; Wnt2a
• Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:19686689). Functions as upstream regulator of FGF10 expression (PubMed:19686689). Plays an important role in embryonic lung development (PubMed:19686689). May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (PubMed:20018874).[UniProtKB/Swiss-Prot Function]