Human BAMBI activation kit by CRISPRa

CAT#: GA108550

BAMBI CRISPRa kit - CRISPR gene activation of human BMP and activin membrane bound inhibitor

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: BAMBI
• Locus ID: 25805
• Kit Components:

  GA108550G1, BAMBI gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108550G2, BAMBI gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108550G3, BAMBI gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012342
• UniProt ID: Q13145
• Synonyms: NMA
• Summary: This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]