Human DUSP10 activation kit by CRISPRa

CAT#: GA107729

DUSP10 CRISPRa kit - CRISPR gene activation of human dual specificity phosphatase 10

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: DUSP10
• Locus ID: 11221
• Kit Components:

  GA107729G1, DUSP10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107729G2, DUSP10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107729G3, DUSP10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007207, NM_144728, NM_144729, NR_111939, NR_111940
• UniProt ID: Q9Y6W6
• Synonyms: MKP-5; MKP5
• Summary: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]