Human Prostaglandin E Synthase (PTGES) activation kit by CRISPRa

CAT#: GA106381

PTGES CRISPRa kit - CRISPR gene activation of human prostaglandin E synthase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PTGES
• Locus ID: 9536
• Kit Components:

  GA106381G1, Prostaglandin E Synthase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106381G2, Prostaglandin E Synthase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106381G3, Prostaglandin E Synthase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004878, NM_198797
• UniProt ID: O14684
• Synonyms: MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1; PGES; PIG12; PP102; PP1294; TP53I12
• Summary: The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]