Human PTPLA (HACD1) activation kit by CRISPRa

CAT#: GA106132

HACD1 CRISPRa kit - CRISPR gene activation of human 3-hydroxyacyl-CoA dehydratase 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: HACD1
• Locus ID: 9200
• Kit Components:

  GA106132G1, PTPLA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106132G2, PTPLA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106132G3, PTPLA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014241
• UniProt ID: B0YJ81
• Synonyms: CAP; PTPLA
• Summary: The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]