Human ALDH4A1 activation kit by CRISPRa

CAT#: GA105739

ALDH4A1 CRISPRa kit - CRISPR gene activation of human aldehyde dehydrogenase 4 family member A1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ALDH4A1
• Locus ID: 8659
• Kit Components:

  GA105739G1, ALDH4A1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105739G2, ALDH4A1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105739G3, ALDH4A1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161504, NM_001319218, NM_003748, NM_170726
• UniProt ID: P30038
• Synonyms: ALDH4; P5CD; P5CDh
• Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009]