Human EPX activation kit by CRISPRa

CAT#: GA105466

EPX CRISPRa kit - CRISPR gene activation of human eosinophil peroxidase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: EPX
• Locus ID: 8288
• Kit Components:

  GA105466G1, EPX gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105466G2, EPX gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105466G3, EPX gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000502
• UniProt ID: P11678
• Synonyms: EPO; EPP; EPX-PEN
• Summary: This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]