Human SKP1 activation kit by CRISPRa

CAT#: GA104426

SKP1 CRISPRa kit - CRISPR gene activation of human S-phase kinase associated protein 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: SKP1
• Locus ID: 6500
• Kit Components:

  GA104426G1, SKP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104426G2, SKP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104426G3, SKP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006930, NM_170679
• UniProt ID: P63208
• Synonyms: EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L
• Summary: This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]