Human Fibrinogen beta chain (FGB) activation kit by CRISPRa

CAT#: GA101567

FGB CRISPRa kit - CRISPR gene activation of human fibrinogen beta chain

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: FGB
• Locus ID: 2244
• Kit Components:

  GA101567G1, Fibrinogen beta chain gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101567G2, Fibrinogen beta chain gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101567G3, Fibrinogen beta chain gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001184741, NM_005141
• UniProt ID: P02675
• Synonyms: HEL-S-78p
• Summary: The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020]