Human Estrogen Receptor beta (ESR2) activation kit by CRISPRa

CAT#: GA101462

ESR2 CRISPRa kit - CRISPR gene activation of human estrogen receptor 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ESR2
• Locus ID: 2100
• Kit Components:

  GA101462G1, Estrogen Receptor beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101462G2, Estrogen Receptor beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101462G3, Estrogen Receptor beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040275, NM_001040276, NM_001214902, NM_001214903, NM_001271876, NM_001271877, NM_001291712, NM_001291723, NM_001437, NR_073496, NR_073497, NR_073505
• UniProt ID: Q92731
• Synonyms: ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2
• Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]