Human DCC activation kit by CRISPRa

CAT#: GA101148

DCC CRISPRa kit - CRISPR gene activation of human DCC netrin 1 receptor

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: DCC
• Locus ID: 1630
• Kit Components:

  GA101148G1, DCC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101148G2, DCC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101148G3, DCC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005215
• UniProt ID: P43146
• Synonyms: CRC18; CRCR1; IGDCC1; MRMV1; NTN1R1
• Summary: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]