Human D Amino Acid Oxidase (DAO) activation kit by CRISPRa

CAT#: GA101134

DAO CRISPRa kit - CRISPR gene activation of human D-amino acid oxidase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: DAO
• Locus ID: 1610
• Kit Components:

  GA101134G1, D Amino Acid Oxidase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101134G2, D Amino Acid Oxidase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101134G3, D Amino Acid Oxidase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001917
• UniProt ID: P14920
• Synonyms: DAAO; DAMOX; OXDA
• Summary: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]