Human BMP4 activation kit by CRISPRa

CAT#: GA100448

BMP4 CRISPRa kit - CRISPR gene activation of human bone morphogenetic protein 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: BMP4
• Locus ID: 652
• Kit Components:

  GA100448G1, BMP4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100448G2, BMP4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100448G3, BMP4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001202, NM_130850, NM_130851, NM_001347912, NM_001347913, NM_001347914, NM_001347915, NM_001347916, NM_001347917
• UniProt ID: P12644
• Synonyms: BMP2B; BMP2B1; MCOPS6; OFC11; ZYME
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]